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Article

Common and rare genetic variants predisposing females to unexplained recurrent pregnancy loss.

Nature communications - 17 Jul 2024

Sonehara Kyuto, Yano Yoshitaka, Naito Tatsuhiko, Goto Shinobu, Yoshihara Hiroyuki, Otani Takahiro, Ozawa Fumiko, Kitaori Tamao, Matsuda Koichi, Nishiyama Takashi, Okada Yukinori, Sugiura-Ogasawara Mayumi

Abstract excerpt

Recurrent pregnancy loss (RPL) is a major reproductive health issue with multifactorial causes, affecting 2.6% of all pregnancies worldwide. Nearly half of the RPL cases lack clinically identifiable causes (e.g., antiphospholipid syndrome, uterine anomalies, and parental chromosomal abnormalities), referred to as unexplained RPL (uRPL). Here, we perform a genome-wide association study focusing on uRPL in 1,728...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39019884
DOI: 10.1038/s41467-024-49993-5
PMCID: PMC11255296

Genes

CDH11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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