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Article

Janus Kinase 2 Regulates Transcription Factor EB Expression and Autophagy Completion in Glomerular Podocytes.

Journal of the American Society of Nephrology : JASN - 1 Sept 2017

Alghamdi Tamadher A, Majumder Syamantak, Thieme Karina, Batchu Sri N, White Kathryn E, Liu Youan, Brijmohan Angela S, Bowskill Bridgit B, Advani Suzanne L, Woo Minna, Advani Andrew

Abstract excerpt

The nonreceptor kinase Janus kinase 2 (JAK2) has garnered attention as a promising therapeutic target for the treatment of CKD. However, being ubiquitously expressed in the adult, JAK2 is also likely to be necessary for normal organ function. Here, we investigated the phenotypic effects of JAK2 deficiency. Mice in which JAK2 had been deleted from podocytes exhibited an elevation in urine albumin excretion that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28424277
DOI: 10.1681/ASN.2016111208
PMCID: PMC5576936

Genes

JAK2
TFEB
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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