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TFEB and TFE3 drive kidney cystogenesis and tumorigenesis

29 Mar 2023

Abstract excerpt

Birt-Hogg-Dubé (BHD) syndrome is an inherited familial cancer syndrome characterized by the development of cutaneous lesions, pulmonary cysts, renal tumors and cysts and caused by loss-of-function pathogenic variants in the gene encoding the tumor-suppressor protein folliculin (FLCN). FLCN acts as a negative regulator of TFEB and TFE3 transcription factors, master controllers of lysosomal biogenesis and...

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PMID: 36987696
DOI: 10.15252/emmm.202216877

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