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Article

Sources of Cancer Neoantigens beyond Single-Nucleotide Variants.

International journal of molecular sciences - 4 Sept 2022

Capietto Aude-Hélène, Hoshyar Reyhane, Delamarre Lélia

Abstract excerpt

The success of checkpoint blockade therapy against cancer has unequivocally shown that cancer cells can be effectively recognized by the immune system and eliminated. However, the identity of the cancer antigens that elicit protective immunity remains to be fully explored. Over the last decade, most of the focus has been on somatic mutations derived from non-synonymous single-nucleotide variants (SNVs) and small...

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Identifiers

PMID: 36077528
DOI: 10.3390/ijms231710131
PMCID: PMC9455963

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