Article

Somatic Mutations and Neoepitope Homology in Melanomas Treated with CTLA-4 Blockade

2016-11-17

Abstract excerpt

Immune checkpoint inhibitors are promising treatments for patients with a variety of malignancies. Toward understanding the determinants of response to immune checkpoint inhibitors, it was previously demonstrated that somatic mutation burden is associated with benefit and a hypothesis was posited that neoantigen homology to pathogens may in part explain the link between somatic mutations and response. To further e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4c51e17f-9f73-586b-b919-00cc8c1da96f
DOI: 10.1101/088286

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Somatic Mutations and Neoepitope Homology in Melanomas Treated with CTLA-4 BlockadeDOI 10.1101/088286Read

Somatic Mutations and Neoepitope Homology in Melanomas Treated with CTLA-4 Blockade.Semantic proximity Read

Genetic basis for clinical response to CTLA-4 blockade in melanoma.Semantic proximity Read

Prediction of Immunotherapy Response in Melanoma through Combined Modeling of Neoantigen Burden and Immune-Related Resistance MechanismsSemantic proximity Read

Is tumor mutational burden predictive of response to immunotherapy?Semantic proximity Read

Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma.Semantic proximity Read

INAEME: Integral Neoantigen Analysis with Entirety of Mutational EventsSemantic proximity Read

The role of neoantigens and tumor mutational burden in cancer immunotherapy: advances, mechanisms, and perspectives.Semantic proximity Read

Identification and characterization of neoantigen-reactive CD8+ T cells following checkpoint blockade therapy in a pan-cancer settingSemantic proximity Read

neoANT-HILL: an integrated tool for identification of potential neoantigensSemantic proximity Read

Construction and validation of an immunoediting-based optimized neoantigen load (ioTNL) model to predict the response and prognosis of immune checkpoint therapy in various cancers.Semantic proximity Read

Integrated genomic analysis identifies a genetic mutation model predicting response to immune checkpoint inhibitors in melanoma.Semantic proximity Read

neoANT-HILL: an integrated tool for identification of potential neoantigensSemantic proximity Read