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Article

How a Mutation that Slows Aging Can Also Disproportionately Extend End-of-Life Decrepitude.

Cell reports - 18 Apr 2017

Podshivalova Katie, Kerr Rex A, Kenyon Cynthia

Abstract excerpt

The goal of aging research is to extend healthy, active life. For decades, C. elegans daf-2 insulin/insulin-like growth factor 1 (IGF-1) receptor mutants have served as a model for extended lifespan and youthfulness. However, a recent report suggested that their longevity is associated with an undesirable phenotype: a disproportionately long period of decrepitude at the end of life. In the human population, such...

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Identifiers

PMID: 28423308
DOI: 10.1016/j.celrep.2017.03.062
PMCID: PMC5526670

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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