Article
The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility.
Oncogene - 2 Feb 2012
Benes C H, Poulogiannis G, Cantley L C, Soltoff S P
Abstract excerpt
Multiple SRC-family kinases (SFKs) are commonly activated in carcinoma and appear to have a role in metastasis through incompletely understood mechanisms. Recent studies have shown that CDCP1 (CUB (complement C1r/C1s, Uegf, Bmp1) Domain-Containing Protein-1) is a transmembrane protein and an SRC substrate potentially involved in metastasis. Here we show that increased SFK and CDCP1 tyrosine phosphorylation is,...
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