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Article

Membrane type 1 matrix metalloproteinase (MT1-MMP) ubiquitination at Lys581 increases cellular invasion through type I collagen.

The Journal of biological chemistry - 30 Mar 2012

Eisenach Patricia A, de Sampaio Pedro Corrêa, Murphy Gillian, Roghi Christian

Abstract excerpt

Membrane type 1 matrix metalloproteinase (MT1-MMP/MMP14) is a zinc-dependent type I transmembrane metalloproteinase playing pivotal roles in the regulation of pericellular proteolysis and cellular migration. Elevated expression levels of MT1-MMP have been demonstrated to correlate with a poor prognosis in cancer. MT1-MMP has a short intracellular domain (ICD) that has been shown to play important roles in...

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Topics

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Share to Collagen Type I
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Space

Share to Lysine

Share to Matrix Metalloproteinase 14

Share to Proteolysis

Share to Proto-Oncogene Proteins pp60(c-src)

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Source

Open in PubMed Open full text

Identifiers

PMID: 22315223
DOI: 10.1074/jbc.M111.306340
PMCID: PMC3322893

Genes

MMP14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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