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Article

Structures of C1q-like proteins reveal unique features among the C1q/TNF superfamily.

Structure (London, England : 1993) - 7 Apr 2015

Ressl Susanne, Vu Brandon K, Vivona Sandro, Martinelli David C, Südhof Thomas C, Brunger Axel T

Abstract excerpt

C1q-like (C1QL) -1, -2, and -3 proteins are encoded by homologous genes that are highly expressed in brain. C1QLs bind to brain-specific angiogenesis inhibitor 3 (BAI3), an adhesion-type G-protein coupled receptor that may regulate dendritic morphology by organizing actin filaments. To begin to understand the function of C1QLs, we determined high-resolution crystal structures of the globular C1q-domains of C1QL1,...

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Identifiers

PMID: 25752542
DOI: 10.1016/j.str.2015.01.019

Genes

TNF

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