Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Homoharringtonine exhibits potent anti-tumor effect and modulates DNA epigenome in acute myeloid leukemia by targeting SP1/TET1/5hmC

11 Apr 2019

Abstract excerpt

Homoharringtonine, a plant alkaloid, has been reported to suppress protein synthesis and has been approved by the US Food and Drug Administration for the treatment of chronic myeloid leukemia. Here we show that in acute myeloid leukemia (AML), homoharringtonine potently inhibits cell growth/viability and induces cell cycle arrest and apoptosis, significantly inhibits disease progression in vivo, and substantially...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Epigenetics and DNA Methylation
Share to Histone Deacetylase Inhibitors Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30975912
DOI: 10.3324/haematol.2018.208835

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Homoharringtonine exhibits potent anti-tumor effect and modulates DNA epigenome in acute myeloid leukemia by targeting SP1/TET1/5hmCPMID 30975912Read ↗

Traditional Chinese medicine for acute myelocytic leukemia therapy: exploiting epigenetic targetsSemantic proximity Read ↗

Thymoquinone Enhances Apoptosis of K562 Chronic Myeloid Leukemia Cells through Hypomethylation of SHP-1 and Inhibition of JAK/STAT Signaling PathwaySemantic proximity Read ↗

Cell-free DNA 5-hydroxymethylcytosine is an emerging marker of acute myeloid leukemiaSemantic proximity Read ↗

Characterization of acute myeloid leukemia based on levels of global hydroxymethylation.Semantic proximity Read ↗

Homoharringtonine deregulates MYC transcriptional expression by directly binding NF-κB repressing factorSemantic proximity Read ↗

Homoharringtonine overcomes the negative impact of genetic patterns on venetoclax plus azacitidine regimen in relapsed/refractory acute myeloid leukemia: a multi-center, cohort studySemantic proximity Read ↗

5-Hydroxymethylcytosine: a key epigenetic mark in cancer and chemotherapy responseSemantic proximity Read ↗

Epigenetic Function of TET Family, 5-Methylcytosine, and 5-Hydroxymethylcytosine in Hematologic MalignanciesSemantic proximity Read ↗

Mitochondrial complex I inhibition by homoharringtonine: A novel strategy for suppression of chronic myeloid leukemia.Semantic proximity Read ↗

Targeting BMAL1 reverses drug resistance of acute myeloid leukemia cells and promotes ferroptosis through HMGB1-GPX4 signaling pathwaySemantic proximity Read ↗

A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations.Semantic proximity Read ↗

Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persistersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.