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DNMT3A R882H mutation promotes acute leukemic cell survival by regulating glycolysis through the NRF2/NQO1 axis.

Cellular signalling - 1 May 2023

Chu Xuan, Zhong Liang, Dan Wenran, Wang Xiao, Zhang Zhonghui, Liu Zhenyan, Lu Yang, Shao Xin, Zhou Ziwei, Chen Shuyu, Liu Beizhong

Abstract excerpt

BACKGROUND: Studies have confirmed that acute myeloid leukemia (AML) cells with DNA methyltransferase 3A Arg882His (DNMT3A R882H) mutation show an increased proliferation capability. However, the associated mechanism is still unclear. Glycolysis is involved in regulating malignant proliferation of cancer cell. Hence, we analyzed whether the DNMT3A R882H mutation interferes with glycolysis and thereby influences...

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PMID: 36758683
DOI: 10.1016/j.cellsig.2023.110626

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