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Article

How does influenza virus a escape from amantadine?

The journal of physical chemistry. B - 1 Jul 2010

Qin Guangrong, Yu Kunqian, Shi Ting, Luo Cheng, Li Guohui, Zhu Weiliang, Jiang Hualiang

Abstract excerpt

Antiflu drugs such as amantadine (AMT) were reported to be insensitive to influenza A virus gradually after their marketing. Mutation experiments indicate that the trans-membrane domain of M2 protein plays an essential role in AMT resistance, especially the S31N mutation. To investigate the details of structure and mechanism, molecular dynamics (MD) simulations and quantum mechanics/molecular mechanics (QM/MM)...

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Identifiers

PMID: 20521806
DOI: 10.1021/jp911588y

Genes

AMT

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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