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Article

Chemical Probes for Blocking of Influenza A M2 Wild-type and S31N Channels.

ACS chemical biology - 18 Sept 2020

Tzitzoglaki Christina, McGuire Kelly, Lagarias Panagiotis, Konstantinidi Athina, Hoffmann Anja, Fokina Natalie A, Ma Chulong, Papanastasiou Ioannis P, Schreiner Peter R, Vázquez Santiago, Schmidtke Michaela, Wang Jun, Busath David D, Kolocouris Antonios

Abstract excerpt

We report on using the synthetic aminoadamantane-CH2-aryl derivatives 1-6 as sensitive probes for blocking M2 S31N and influenza A virus (IAV) M2 wild-type (WT) channels as well as virus replication in cell culture. The binding kinetics measured using electrophysiology (EP) for M2 S31N channel are very dependent on the length between the adamantane moiety and the first ring of the aryl headgroup realized in 2 and...

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Identifiers

PMID: 32786258
DOI: 10.1021/acschembio.0c00553
PMCID: PMC8051587

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