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Article

CDK19 is a Regulator of Triple-Negative Breast Cancer Growth

2018-05-10

Abstract excerpt

Triple-negative breast cancer (TNBC) is a poor prognosis disease with no clinically approved targeted therapies. Here, using in vitro and in vivo RNA interference (RNAi) screens in TNBC patient-derived xenografts (PDX), we identify cyclin dependent kinase 19 (CDK19) as a potential therapeutic target. Using in vitro and in vivo TNBC PDX models, we validated the inhibitory effect of CDK19 knockdown on tumor ini...

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Literature Corpus work
5def8b59-8f5a-53f2-9492-5c5cc7d49844
DOI
10.1101/317776
Open publication

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CDK19 is a Regulator of Triple-Negative Breast Cancer GrowthDOI 10.1101/317776
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