Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

KRAS/NF-κB/YY1/miR-489 Signaling Axis Controls Pancreatic Cancer Metastasis

28 Oct 2016

Abstract excerpt

KRAS activation occurring in more than 90% of pancreatic ductal adenocarcinomas (PDAC) drives progression and metastasis, but the underlying mechanisms involved in these processes are still poorly understood. Here, we show how KRAS acts through inflammatory NF-κB signaling to activate the transcription factor YY1, which represses expression of the tumor suppressor gene miR-489. In PDAC cells, repression of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to MicroRNA in disease regulation
Share to Pancreatic and Hepatic Oncology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27793842
DOI: 10.1158/0008-5472.can-16-1898

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

KRAS/NF-κB/YY1/miR-489 Signaling Axis Controls Pancreatic Cancer MetastasisPMID 27793842Read ↗

ARF6-AMAP1 pathway induces pancreatic cancer cells to express immunosuppressive chemokinesSemantic proximity Read ↗

Inhibition of ADAM9 promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapySemantic proximity Read ↗

The YY1/miR-548t-5p/CXCL11 signaling axis regulates cell proliferation and metastasis in human pancreatic cancerSemantic proximity Read ↗

KIAA1199 is induced by inflammation and enhances malignant phenotype in pancreatic cancer.Semantic proximity Read ↗

LncRNA ZFAS1 promotes pancreatic adenocarcinoma metastasis via the RHOA/ROCK2 pathway by sponging miR-3924Semantic proximity Read ↗

The long non-coding RNA NEAT1 contributes to aberrant STAT3 signaling in pancreatic cancer and is regulated by a metalloprotease-disintegrin ADAM8/miR-181a-5p axisSemantic proximity Read ↗

Gene Regulation by Antitumor miR-204-5p in Pancreatic Ductal Adenocarcinoma: The Clinical Significance of Direct RACGAP1 RegulationSemantic proximity Read ↗

KRAS promotes tumor metastasis and chemoresistance by repressing RKIP via the MAPK-ERK pathway in pancreatic cancer.Semantic proximity Read ↗

PAFAH1B3 is a KLF9 target gene and promotes proliferation and metastasis in pancreatic cancerSemantic proximity Read ↗

Mutant KRAS promotes NF-κB driven CCL20 chemokine expression in pancreatic ductal adenocarcinomaSemantic proximity Read ↗

Aberrant STAT3 signaling in pancreatic cancer requires the lncRNA NEAT1 regulated by the metalloprotease-disintegrin ADAM8 via miR-181a-5pSemantic proximity Read ↗

Non-canonical ALK7 pathways promote pancreatic cancer metastasis through β-catenin/MMP-mediated basement membrane breakdown and intravasationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.