Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MiR-142-3p is downregulated in aggressive p53 mutant mouse models of pancreatic ductal adenocarcinoma by hypermethylation of its locus.

Cell death & disease - 29 May 2018

Godfrey Jack D, Morton Jennifer P, Wilczynska Ania, Sansom Owen J, Bushell Martin D

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive disease with poor prognostic implications. This is partly due to a large proportion of PDACs carrying mutations in TP53, which impart gain-of-function characteristics that promote metastasis. There is evidence that microRNAs (miRNAs) may play a role in both gain-of-function TP53 mutations and metastasis, but this has not been fully explored in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Azacitidine
Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CpG Islands

Share to DNA (Cytosine-5-)-Methyltransferase 1

Share to Down-Regulation

Share to Neoplasm Invasiveness

Share to Pancreatic Neoplasms

Share to Survival Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 29844410
DOI: 10.1038/s41419-018-0628-4
PMCID: PMC5973943

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MiR-142-3p is downregulated in aggressive p53 mutant mouse models of pancreatic ductal adenocarcinoma by hypermethylation of its locus.PMID 29844410Read ↗

miRNAs in pancreatic cancer progression and metastasisSemantic proximity Read ↗

Genome-Wide CRISPR Screen Identifies Genes Involved in Metastasis of Pancreatic Ductal AdenocarcinomaSemantic proximity Read ↗

Epigenetic Alterations in Pancreatic Cancer Metastasis.Semantic proximity Read ↗

EP300—A miRNA‐regulated metastasis suppressor gene in ductal adenocarcinomas of the pancreasSemantic proximity Read ↗

Genomic Sequencing of Key Genes in Mouse Pancreatic Cancer CellsSemantic proximity Read ↗

The RNA‐binding protein MEX3A is a prognostic factor and regulator of resistance to gemcitabine in pancreatic ductal adenocarcinomaSemantic proximity Read ↗

MicroRNA Profiling Implies New Markers of Gemcitabine Chemoresistance in Mutant p53 Pancreatic Ductal Adenocarcinoma.Semantic proximity Read ↗

Genome‐wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT‐ROBO, ITGA2 and MET signalingSemantic proximity Read ↗

PTEN-Dependent Stabilization of MTSS1 Inhibits Metastatic Phenotype in Pancreatic Ductal Adenocarcinoma.Semantic proximity Read ↗

MicroRNAs of the mir-17~92 cluster regulate multiple aspects of pancreatic tumor development and progression.Semantic proximity Read ↗

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer.Semantic proximity Read ↗

Dual inhibition of FACT and RRM2 suppresses the progression of pancreatic ductal adenocarcinoma driven by the oncohistone H2BG53D.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.