Article
MicroRNA-17-92 cluster regulates pancreatic beta-cell proliferation and adaptation.
Molecular and cellular endocrinology - 5 Dec 2016
Chen Yaxi, Tian Li, Wan Shan, Xie Ying, Chen Xiang, Ji Xiao, Zhao Qian, Wang Chunyu, Zhang Kun, Hock Janet M, Tian Haoming, Yu Xijie
Abstract excerpt
MiR-17-92 cluster contributes to the regulation of mammalian development, aging and tumorigenesis. The functional roles of miR-17-92 in pancreatic beta-cells are largely unknown. In this study, we found that conditional deletion of miR-17-92 in mouse pancreatic beta-cells (miR-17-92βKO) significantly reduces glucose tolerance and the first phase of insulin secretion, despite normal ad libitum fed and fasting...
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