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Article

Spop regulates Gli3 activity and Shh signaling in dorsoventral patterning of the mouse spinal cord.

Developmental biology - 1 Dec 2017

Cai Hongchen, Liu Aimin

Abstract excerpt

Sonic Hedgehog (Shh) signaling regulates the patterning of ventral spinal cord through the effector Gli family of transcription factors. Previous in vitro studies showed that an E3 ubiquitin ligase containing Speckle-type POZ protein (Spop) targets Gli2 and Gli3 for ubiquitination and degradation, but the role of Spop in Shh signaling and mammalian spinal cord patterning remains unknown. Here, we show that loss...

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Identifiers

PMID: 28412462
DOI: 10.1016/j.ydbio.2017.04.002
PMCID: PMC5638672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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