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Article

Epigenetically induced ectopic expression of UNCX impairs the proliferation and differentiation of myeloid cells.

Haematologica - 1 Jul 2017

Daniele Giulia, Simonetti Giorgia, Fusilli Caterina, Iacobucci Ilaria, Lonoce Angelo, Palazzo Antonio, Lomiento Mariana, Mammoli Fabiana, Marsano Renè Massimiliano, Marasco Elena, Mantovani Vilma, Quentmeier Hilmar, Drexler Hans G, Ding Jie, Palumbo Orazio, Carella Massimo, Nadarajah Niroshan, Perricone Margherita, Ottaviani Emanuela, Baldazzi Carmen, Testoni Nicoletta, Papayannidis Cristina, Ferrari Sergio, Mazza Tommaso, Martinelli Giovanni, Storlazzi Clelia Tiziana

Abstract excerpt

We here describe a leukemogenic role of the homeobox gene UNCX, activated by epigenetic modifications in acute myeloid leukemia (AML). We found the ectopic activation of UNCX in a leukemia patient harboring a t(7;10)(p22;p14) translocation, in 22 of 61 of additional cases [a total of 23 positive patients out of 62 (37.1%)], and in 6 of 75 (8%) of AML cell lines. UNCX is embedded within a low-methylation region...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA (Cytosine-5-)-Methyltransferases

Share to DNA Methyltransferase 3A

Share to Epigenesis, Genetic

Share to Leukemia, Myeloid, Acute

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Source

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Identifiers

PMID: 28411256
DOI: 10.3324/haematol.2016.163022
PMCID: PMC5566027

Genes

UNCX
CCNA1
NPM1
PML
RARA
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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