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Article

NKL homeobox gene activities in hematopoietic stem cells, T-cell development and T-cell leukemia

2 Feb 2017

Abstract excerpt

T-cell acute lymphoblastic leukemia (T-ALL) cells represent developmentally arrested T-cell progenitors, subsets of which aberrantly express homeobox genes of the NKL subclass, including TLX1, TLX3, NKX2-1, NKX2-5, NKX3-1 and MSX1. Here, we analyzed the transcriptional landscape of all 48 members of the NKL homeobox gene subclass in CD34+ hematopoietic stem and progenitor cells (HSPCs) and during lymphopoiesis,...

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PMID: 28151996
DOI: 10.1371/journal.pone.0171164

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