Human-relevant Ptpn6 mutation alters immune and hepatic functions during aging.

doi:10.18632/aging.206413

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Article

Human-relevant Ptpn6 mutation alters immune and hepatic functions during aging.

Aging - 28 Aug 2026

Labrada Beisy Laborit, Kumar Amit, Kolnohuz Alona, Pineault Marie, Bellmann Kerstin, Schwab Michael, Gagné Andréanne, Laplante Mathieu, Morissette Mathieu C, Marette André

Abstract excerpt

Src homology region 2-containing phosphatase 1 (SHP-1), encoded by the protein tyrosine phosphatase non-receptor type 6 (PTPN6), regulates immune and metabolic signaling pathways. Although its functions in immune cells and insulin-responsive tissues are separately established, its integrative function in immunometabolic regulation remains unclear. A damaging variant in the PTPN6 gene (Ala455Thr) was discovered in...

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Topics

Protein Tyrosine Phosphatase, Non-Receptor Type 6
Animals
Aging
Liver
Humans
Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Signal Transduction

Mice, Knockout

STAT3 Transcription Factor

Hepatocytes

Insulin Resistance

Male

Source

Open in PubMed

Identifiers

PMID: 42669491
DOI: 10.18632/aging.206413

Genes

PTPN6
STAT3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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