Article

SYK gain-of-function mutation regulates neutrophil functions to drive spontaneous psoriasis

2025-12-08

Abstract excerpt

<title>Abstract</title> <p> Psoriasis is a chronic, complex autoimmune disease characterized by massive immune cells infiltration including neutrophils. Spleen tyrosine kinase (SYK), a cytoplasmic non-receptor tyrosine kinase, has been reported to be essential to maintain the pro- inflammatory phenotype of neutrophils. Nevertheless, the influence of SYK on neutrophil function under psoriasis remains largely unkn...

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Literature Corpus work: 3c849bdc-6b72-52ab-8fff-95115630629d
DOI: 10.21203/rs.3.rs-8234680/v1

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