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Article

Genome-wide detection of single-nucleotide and copy-number variations of a single human cell.

Science (New York, N.Y.) - 21 Dec 2012

Zong Chenghang, Lu Sijia, Chapman Alec R, Xie X Sunney

Abstract excerpt

Kindred cells can have different genomes because of dynamic changes in DNA. Single-cell sequencing is needed to characterize these genomic differences but has been hindered by whole-genome amplification bias, resulting in low genome coverage. Here, we report on a new amplification method-multiple annealing and looping-based amplification cycles (MALBAC)-that offers high uniformity across the genome. Sequencing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23258894
DOI: 10.1126/science.1229164
PMCID: PMC3600412

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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