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Article

Genetic Effects on the Correlation Structure of CVD Risk Factors: Exome-Wide Data From a Ghanaian Population.

Global heart - 1 Jun 2017

Kodaman Nuri, Sobota Rafal S, Asselbergs Folkert W, Oetjens Matthew T, Moore Jason H, Brown Nancy J, Aldrich Melinda C, Williams Scott M

Abstract excerpt

Plasma concentration of plasminogen activator inhibitor-1 (PAI-1) is highly correlated with several cardiovascular disease (CVD) risk factors. It also plays a direct role in CVD, including myocardial infarction and stroke, by impeding the dissolution of thrombi in the blood. Insofar as PAI-1 links CVD's risk factors to its endpoints, genetic variants modulating the relationship between PAI-1 and risk factors may...

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Identifiers

PMID: 28408189
DOI: 10.1016/j.gheart.2017.01.013
PMCID: PMC5642993

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