Article
Genetic variation in hyaluronan metabolism loci is associated with plasma plasminogen activator inhibitor-1 concentration.
Blood - 23 Sept 2010
Lanktree Matthew B, Johansen Christopher T, Anand Sonia S, Davis A Darlene, Miller Ruby, Yusuf Salim, Hegele Robert A
Abstract excerpt
Elevated plasma plasminogen activator inhibitor-1 (PAI-1) concentration is associated with cardiovascular disease risk. PAI-1 is the primary inhibitor of fibrinolysis within both the circulation and the arterial wall, playing roles in both atherosclerosis and thrombosis. To define the heritable component, subjects within the population-based SHARE (Study of Health Assessment and Risk in Ethnic groups) and...
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