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Article

Leptin accelerates the pathogenesis of heterotopic ossification in rat tendon tissues via mTORC1 signaling.

Journal of cellular physiology - 1 Feb 2018

Jiang Huaji, Chen Yuhui, Chen Guorong, Tian Xinggui, Tang Jiajun, Luo Lei, Huang Minjun, Yan Bin, Ao Xiang, Zhou Wen, Wang Liping, Bai Xiaochun, Zhang Zhongmin, Wang Liang, Xian Cory J

Abstract excerpt

Leptin, an adipocyte-derived cytokine associated with bone metabolism, is believed to play a critical role in the pathogenesis of heterotopic ossification (HO). The effect and underlying action mechanism of leptin were investigated on osteogenic differentiation of tendon-derived stem cells (TDSCs) in vitro and the HO formation in rat tendons. Isolated rat TDSCs were treated with various concentrations of leptin...

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Share to Core Binding Factor Alpha 1 Subunit
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Ossification, Heterotopic

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Identifiers

PMID: 28407241
DOI: 10.1002/jcp.25955

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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