Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Mechanism of traumatic heterotopic ossification: In search of injury-induced osteogenic factors.

Journal of cellular and molecular medicine - 1 Oct 2020

Li La, Tuan Rocky S

Abstract excerpt

Heterotopic ossification (HO) is a pathological condition of abnormal bone formation in soft tissue. Three factors have been proposed as required to induce HO: (a) osteogenic precursor cells, (b) osteoinductive agents and (c) an osteoconductive environment. Since Urist's landmark discovery of bone induction in skeletal muscle tissue by demineralized bone matrix, it is generally believed that skeletal muscle...

Topics

Join the communities discussing this publication.

Macrophages
Models, Biological
Ossification, Heterotopic
Osteogenesis
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Wounds and Injuries

Source

Open in PubMed Open full text

Identifiers

PMID: 32853465
DOI: 10.1111/jcmm.15735
PMCID: PMC7576286

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanism of traumatic heterotopic ossification: In search of injury-induced osteogenic factors.PMID 32853465Read ↗

Burn-induced heterotopic ossification from incidence to therapy: key signaling pathways underlying ectopic bone formationSemantic proximity Read ↗

The hypoxic microenvironment: a driving force for heterotopic ossification progressionSemantic proximity Read ↗

Acquired and congenital forms of heterotopic ossification: new pathogenic insights and therapeutic opportunities.Semantic proximity Read ↗

The Survey of Cells Responsible for Heterotopic Ossification Development in Skeletal Muscles—Human and Mouse ModelsSemantic proximity Read ↗

The Convergence of Fracture Repair and Stem Cells: Interplay of Genes, Aging, Environmental Factors and DiseaseSemantic proximity Read ↗

BMP and mTOR signaling in heterotopic ossification: Does their crosstalk provide therapeutic opportunities?Semantic proximity Read ↗

The use of mesenchymal (skeletal) stem cells for treatment of degenerative diseases: Current status and future perspectivesSemantic proximity Read ↗

Leptin accelerates the pathogenesis of heterotopic ossification in rat tendon tissues via mTORC1 signaling.Semantic proximity Read ↗

A review of the biomarkers and in vivo models for the diagnosis and treatment of heterotopic ossification following blast and trauma-induced injuriesSemantic proximity Read ↗

Murine Tissue-Resident PDGFRα+ Fibro-Adipogenic Progenitors Spontaneously Acquire Osteogenic Phenotype in an Altered Inflammatory Environment.Semantic proximity Read ↗

Cellular biology of fracture healingSemantic proximity Read ↗

The pathogenesis of osteonecrosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.