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Pathogenesis of thoracic ossification of the ligamentum flavum

31 Oct 2024

Abstract excerpt

Thoracic ossification of the ligamentum flavum (TOLF) is characterized by ectopic ossification of the ligamentum flavum in the thoracic spine and is considered the main cause of thoracic spinal stenosis and spinal cord disease. Osteoblast specific transcription factor Osterix (Osx) is required for bone formation, and there is no bone formation or ossification without Osx. Surgical intervention is recognized as...

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PMID: 39545059
DOI: 10.3389/fphar.2024.1496297

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