Article

Stimulation-responsive enhancers regulate inflammatory gene activation through retention and modification of H2A.Z-variant accessible nucleosomes

2022-09-13

Abstract excerpt

Prostaglandin E2 (PGE 2 ) and 16,16-dimethyl-PGE 2 (dmPGE 2 ) are important regulators of hematopoietic stem and progenitor cell (HSPC) fate and offer potential to enhance stem cell therapies 1,2 . The mechanism of gene regulation in response to dmPGE 2 is poorly understood. Here, we show that dmPGE 2 regulates inflammatory gene induction by modulating the chromatin architecture and activity of enhancer elem...

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Literature Corpus work: c9ed29fa-cefe-5eb0-90d9-f99395603555
DOI: 10.1101/2022.09.12.507565

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Stimulation-responsive enhancers regulate inflammatory gene activation through retention and modification of H2A.Z-variant accessible nucleosomesDOI 10.1101/2022.09.12.507565Read

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