Article

HIRA-SETDB1-H3K9me3 axis regulate chromatin architecture in chronic myeloid leukemia cells

2024-11-03

Abstract excerpt

Histone cell cycle regulator A (HIRA) confers chromatin accessibility and regulates developmental hematopoiesis. But whether HIRA displays similar role in leukemia, a condition caused by abnormalities during hematopoiesis, remain elusive. Here we show that HIRA interact with heterochromatin cluster in Chronic Myeloid Leukemia, K562, cells. FRAP, FLIM-FRET and ATAC-sequencing analysis revealed increased chromatin c...

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Literature Corpus work: a56b1371-b4a6-5be6-b123-4f5d0ea224eb
DOI: 10.1101/2024.11.01.621462

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