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Article

Caveolae-localized L-type Ca2+ channels do not contribute to function or hypertrophic signalling in the mouse heart.

Cardiovascular research - 1 Jun 2017

Correll Robert N, Makarewich Catherine A, Zhang Hongyu, Zhang Chen, Sargent Michelle A, York Allen J, Berretta Remus M, Chen Xiongwen, Houser Steven R, Molkentin Jeffery D

Abstract excerpt

AIMS: L-type Ca2+ channels (LTCCs) in adult cardiomyocytes are localized to t-tubules where they initiate excitation-contraction coupling. Our recent work has shown that a subpopulation of LTCCs found at the surface sarcolemma in caveolae of adult feline cardiomyocytes can also generate a Ca2+ microdomain that activates nuclear factor of activated T-cells signaling and cardiac hypertrophy, although the relevance...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28402392
DOI: 10.1093/cvr/cvx046
PMCID: PMC5852617

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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