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Article

Caveolin-3 KO disrupts t-tubule structure and decreases t-tubular ICa density in mouse ventricular myocytes.

American journal of physiology. Heart and circulatory physiology - 1 Nov 2018

Bryant Simon M, Kong Cherrie H T, Watson Judy J, Gadeberg Hanne C, Roth David M, Patel Hemal H, Cannell Mark B, James Andrew F, Orchard Clive H

Abstract excerpt

Caveolin-3 (Cav-3) is a protein that has been implicated in t-tubule formation and function in cardiac ventricular myocytes. In cardiac hypertrophy and failure, Cav-3 expression decreases, t-tubule structure is disrupted, and excitation-contraction coupling is impaired. However, the extent to which the decrease in Cav-3 expression underlies these changes is unclear. We therefore investigated the structure and...

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Identifiers

PMID: 30028203
DOI: 10.1152/ajpheart.00209.2018
PMCID: PMC6415741

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