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Article

Novel insights on the relationship between T-tubular defects and contractile dysfunction in a mouse model of hypertrophic cardiomyopathy.

Journal of molecular and cellular cardiology - 1 Feb 2016

Crocini C, Ferrantini C, Scardigli M, Coppini R, Mazzoni L, Lazzeri E, Pioner J M, Scellini B, Guo A, Song L S, Yan P, Loew L M, Tardiff J, Tesi C, Vanzi F, Cerbai E, Pavone F S, Sacconi L, Poggesi C

Abstract excerpt

Abnormalities of cardiomyocyte Ca(2+) homeostasis and excitation-contraction (E-C) coupling are early events in the pathogenesis of hypertrophic cardiomyopathy (HCM) and concomitant determinants of the diastolic dysfunction and arrhythmias typical of the disease. T-tubule remodelling has been reported to occur in HCM but little is known about its role in the E-C coupling alterations of HCM. Here, the role of...

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Identifiers

PMID: 26714042
DOI: 10.1016/j.yjmcc.2015.12.013
PMCID: PMC4767219

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