Article
Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas.
Acta neuropathologica communications - 30 Oct 2017
Salloum Ralph, McConechy Melissa K, Mikael Leonie G, Fuller Christine, Drissi Rachid, DeWire Mariko, Nikbakht Hamid, De Jay Nicolas, Yang Xiaodan, Boue Daniel, Chow Lionel M L, Finlay Jonathan L, Gayden Tenzin, Karamchandani Jason, Hummel Trent R, Olshefski Randal, Osorio Diana S, Stevenson Charles, Kleinman Claudia L, Majewski Jacek, Fouladi Maryam, Jabado Nada
Abstract excerpt
Pediatric high-grade gliomas (pHGGs) are aggressive neoplasms representing approximately 20% of brain tumors in children. Current therapies offer limited disease control, and patients have a poor prognosis. Empiric use of targeted therapy, especially at progression, is increasingly practiced despite a paucity of data regarding temporal and therapy-driven genomic evolution in pHGGs. To study the genetic landscape...
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