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Article

Plasma Lipidomics, Gut Microbiota Profile, and Phenotype of Adipose Tissue in an ApoE-/- Mouse Model of Plaque Instability.

Frontiers in bioscience (Landmark edition) - 21 Mar 2025

Yang Guanlin, Tan Xin, Zhai Qiong, Wang Yuewu, Zhang Xuan, Zhao Pengwei, Liang Fangyuan, Lu Jingkun, Bao LiLi

Abstract excerpt

BACKGROUND: An appropriate animal model that can simulate the pathological process of atherosclerosis is urgently needed to improve treatment strategies. This study aimed to develop a new atherosclerosis model using ApoE-/- mice and to characterize lipidomics, gut microbiota profiles, and phenotypic alterations in adipose tissue using this model. METHODS: After a 14- or 18-week high-fat diet (HFD), male ApoE-/-...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40152393
DOI: 10.31083/FBL27236

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UCP1

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