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Article

Structure of an aprataxin-DNA complex with insights into AOA1 neurodegenerative disease.

Nature structural & molecular biology - 9 Oct 2011

Tumbale Percy, Appel C Denise, Kraehenbuehl Rolf, Robertson Patrick D, Williams Jessica S, Krahn Joe, Ahel Ivan, Williams R Scott

Abstract excerpt

DNA ligases finalize DNA replication and repair through DNA nick-sealing reactions that can abort to generate cytotoxic 5'-adenylation DNA damage. Aprataxin (Aptx) catalyzes direct reversal of 5'-adenylate adducts to protect genome integrity. Here the structure of a Schizosaccharomyces pombe Aptx-DNA-AMP-Zn(2+) complex reveals active site and DNA interaction clefts formed by fusing a histidine triad (HIT)...

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Source

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Identifiers

PMID: 21984210
DOI: 10.1038/nsmb.2146
PMCID: PMC3210380

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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