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Article

Dose-dependent functions of fibroblast growth factor 9 regulate the fate of murine XY primordial germ cells†

23 Dec 2016

Abstract excerpt

Male differentiation of primordial germ cells (PGCs) is initiated by the inhibition of entry into meiosis and exposure to male-inducing factor(s), which are regulated by somatic elements of the developing gonad. Fibroblast growth factor 9 (FGF9) produced by pre-Sertoli cells is essential for male gonadal differentiation and also contributes to survival and male differentiation of XY PGCs. However, it is not clear...

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PMID: 28395336
DOI: 10.1095/biolreprod.116.143941

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