Article
The PGD2 pathway, independently of FGF9, amplifies SOX9 activity in Sertoli cells during male sexual differentiation.
Development (Cambridge, England) - 1 Jun 2009
Moniot Brigitte, Declosmenil Faustine, Barrionuevo Francisco, Scherer Gerd, Aritake Kosuke, Malki Safia, Marzi Laetitia, Cohen-Solal Anne, Georg Ina, Klattig Jürgen, Englert Christoph, Kim Yuna, Capel Blanche, Eguchi Naomi, Urade Yoshihiro, Boizet-Bonhoure Brigitte, Poulat Francis
Abstract excerpt
Activation by the Y-encoded testis determining factor SRY and maintenance of expression of the Sox9 gene encoding the central transcription factor of Sertoli cell differentiation are key events in the mammalian sexual differentiation program. In the mouse XY gonad, SOX9 upregulates Fgf9, which initiates a Sox9/Fgf9 feedforward loop, and Sox9 expression is stimulated by the prostaglandin D2 (PGD2) producing...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.