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Article

FGF9, activin and TGFβ promote testicular characteristics in an XX gonad organ culture model

5 Aug 2016

Abstract excerpt

Testis development is dependent on the key sex-determining factors SRY and SOX9, which activate the essential ligand FGF9. Although FGF9 plays a central role in testis development, it is unable to induce testis formation on its own. However, other growth factors, including activins and TGFβs, also present testis during testis formation. In this study, we investigated the potential of FGF9 combined with activin...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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Identifiers

PMID: 27495231
DOI: 10.1530/rep-16-0293

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