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Article

Identifying disruptors of male germ cell development by small molecule screening in ex vivo gonad cultures

30 Apr 2013

Abstract excerpt

BACKGROUND: Germ cell development involves formation of the spermatogenic or oogenic lineages from the bipotential primordial germ cells. Signaling mechanisms in the fetal testis and ovary determine whether germ cells enter the male or female developmental pathway, respectively. These signaling processes underpin an important phase of germ cell development, disruption of which can lead to failed germ cell...

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PMID: 23631647
DOI: 10.1186/1756-0500-6-168

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