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Sexually dimorphic development of mouse primordial germ cells: switching from oogenesis to spermatogenesis

1 Mar 2002

Abstract excerpt

During embryogenesis, primordial germ cells (PGCs) have the potential to enter either spermatogenesis or oogenesis. In a female genital ridge, or in a non-gonadal environment, PGCs develop as meiotic oocytes. However, male gonadal somatic cells inhibit PGCs from entering meiosis and direct them to a spermatogenic fate. We have examined the ability of PGCs from male and female embryos to respond to the...

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PMID: 11874911
DOI: 10.1242/dev.129.5.1155

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