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Article

FGF9 promotes survival of germ cells in the fetal testis

16 Mar 2006

Abstract excerpt

In addition to its role in somatic cell development in the testis, our data have revealed a role for Fgf9 in XY germ cell survival. In Fgf9-null mice, germ cells in the XY gonad decline in numbers after 11.5 days post coitum (dpc), while germ cell numbers in XX gonads are unaffected. We present evidence that germ cells resident in the XY gonad become dependent on FGF9 signaling between 10.5 dpc and 11.5 dpc, and...

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PMID: 16540514
DOI: 10.1242/dev.02303

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