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SMAD2 and p38 signaling pathways act in concert to determine XY primordial germ cell fate in mice

20 Jan 2015

Abstract excerpt

The sex of primordial germ cells (PGCs) is determined in developing gonads on the basis of cues from somatic cells. In XY gonads, sex-determining region Y (SRY) triggers fibroblast growth factor 9 (FGF9) expression in somatic cells. FGF signaling, together with downstream nodal/activin signaling, promotes male differentiation in XY germ cells by suppressing retinoic acid (RA)-dependent meiotic entry and inducing...

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PMID: 25605784
DOI: 10.1242/dev.119446

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