Article

Src-Family B Kinase Inhibition Promotes Lung Endothelial Dysfunction and Guides Drug Discovery

2021-09-27

Abstract excerpt

Protein tyrosine kinase (PTK) inhibition is efficacious in treating conditions ranging from cancer to fibrosis but can be limited by endothelial cell dysfunction. In trials of protein tyrosine kinase inhibitors (TKIs) a broad range of vascular effects is observed, inducing clinically detrimental endothelial cell apoptosis, impaired barrier function, or improved pulmonary vascular resistance in pulmonary arterial h...

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Literature Corpus work: 957de538-2be5-52a2-ad27-8c4397587f77
DOI: 10.1101/2021.09.27.462034

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