Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1.

Nature immunology - 1 Jun 2017

Newman Rebecca, Ahlfors Helena, Saveliev Alexander, Galloway Alison, Hodson Daniel J, Williams Robert, Besra Gurdyal S, Cook Charlotte N, Cunningham Adam F, Bell Sarah E, Turner Martin

Abstract excerpt

RNA-binding proteins of the ZFP36 family are best known for inhibiting the expression of cytokines through binding to AU-rich elements in the 3' untranslated region and promoting mRNA decay. Here we identified an indispensable role for ZFP36L1 as the regulator of a post-transcriptional hub that determined the identity of marginal-zone B cells by promoting their proper localization and survival. ZFP36L1 controlled...

Topics

Join the communities discussing this publication.

B-Lymphocytes
Cell Adhesion
Enzyme-Linked Immunosorbent Assay
Fluorescent Antibody Technique
Interferon Regulatory Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kruppel-Like Transcription Factors

Lymphoid Tissue

Sequence Analysis, RNA

Source

Open in PubMed Open full text

Identifiers

PMID: 28394372
DOI: 10.1038/ni.3724
PMCID: PMC5438597

Genes

KLF2
ZFP36

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1.PMID 28394372Read ↗

Post-Transcriptional Regulation of Immune Responses and Inflammatory Diseases by RNA-Binding ZFP36 Family Proteins.Semantic proximity Read ↗

The RNA-Binding Proteins Zfp36l1 and Zfp36l2 Enforce the Thymic β-Selection Checkpoint by Limiting DNA Damage Response Signaling and Cell Cycle Progression.Semantic proximity Read ↗

IRF4 Has a Unique Role in Early B Cell Development and Acts Prior to CD21 Expression to Control Marginal Zone B Cell Numbers.Semantic proximity Read ↗

BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanismsSemantic proximity Read ↗

IRF4 controls the positioning of mature B cells in the lymphoid microenvironments by regulating NOTCH2 expression and activity.Semantic proximity Read ↗

Bcl6-Mediated Transcriptional Regulation of Follicular Helper T cells (TFH)Semantic proximity Read ↗

ZNF423: Transcriptional modulation in development and cancerSemantic proximity Read ↗

Bcl-6 is the nexus transcription factor of T follicular helper cells via repressor-of-repressor circuits.Semantic proximity Read ↗

Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment.Semantic proximity Read ↗

Architecture and dynamics of the transcription factor network that regulates B-to-plasma cell differentiation.Semantic proximity Read ↗

KAP1 regulates gene networks controlling T-cell development and responsiveness.Semantic proximity Read ↗

The BCL6 RD2 domain governs commitment of activated B cells to form germinal centers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.