Article
IRF4 controls the positioning of mature B cells in the lymphoid microenvironments by regulating NOTCH2 expression and activity.
The Journal of experimental medicine - 16 Dec 2013
Simonetti Giorgia, Carette Amanda, Silva Kathryn, Wang Haowei, De Silva Nilushi S, Heise Nicole, Siebel Christian W, Shlomchik Mark J, Klein Ulf
Abstract excerpt
The transcription factor interferon regulatory factor-4 (IRF4) is expressed in B cells at most developmental stages. In antigen-activated B cells, IRF4 controls germinal center formation, class-switch recombination, and the generation of plasma cells. Here we describe a novel function for IRF4 in the homeostasis of mature B cells. Inducible deletion of irf4 specifically in B cells in vivo led to the aberrant...
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