Article
Association of C-Type Lectin Mincle with FcεRIβγ Subunits Leads to Functional Activation of RBL-2H3 Cells through Syk.
Scientific reports - 10 Apr 2017
Honjoh Chisato, Chihara Kazuyasu, Yoshiki Hatsumi, Yamauchi Shota, Takeuchi Kenji, Kato Yuji, Hida Yukio, Ishizuka Tamotsu, Sada Kiyonao
Abstract excerpt
Macrophage-inducible C-type lectin (Mincle) interacts with the γ-subunit of high-affinity IgE receptor (FcεRIγ) and activates Syk by recognizing its specific ligand, trehalose-6,6'-dimycolate, a glycolipid produced by Mycobacterium tuberculosis. It has been suggested that mast cells participate in the immune defense against pathogenic microbes including M. tuberculosis, although the functions are still uncertain....
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