Article
The FcRβ- and γ-ITAMs play crucial but distinct roles in the full activation of mast cells induced by IgEκ and Protein L.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2012
Nunomura Satoshi, Kawakami Yuko, Kawakami Toshiaki, Ra Chisei
Abstract excerpt
Previous studies suggested that Protein L (PpL), the bacterial Ig-binding protein, activates mast cells. PpL presumably performs the activation by interacting with membrane-bound IgEκ, but the underlying mechanisms behind the process remain unclear. In the current study, we found that cell-surface FcεRI expression is a critical factor participant in PpL-mediated full activation of murine mast cells, which...
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