Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The pattern recognition receptor, Mincle, is essential for maintaining the M1 macrophage phenotype in acute renal inflammation.

Kidney international - 1 Mar 2017

Lv Lin L, Tang Patrick Ming-Kuen, Li Chun J, You Yong K, Li Jinhong, Huang Xiao-Ru, Ni Jun, Feng Min, Liu Bi C, Lan Hui-Yao

Abstract excerpt

Mincle (macrophage-inducible C-type lectin, Clec4e) is a transmembrane pattern recognition receptor involving the innate immunity, but its role in kidney disease is still unexplored. In the obstructed kidney of the unilateral ureteral obstruction model of renal injury, Mincle was specifically detected in the infiltrating M1 macrophages (CD68+iNOS+ cells) on day one but was rapidly reduced following reduction of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Kidney Injury
Share to Antigens, Differentiation, Myelomonocytic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nephritis

Share to RAW 264.7 Cells

Share to Receptors, Pattern Recognition

Share to Syk Kinase

Share to Transcription Factor RelA

Share to Ureteral Obstruction

Source

Identifiers

PMID: 28017324
DOI: 10.1016/j.kint.2016.10.020

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The pattern recognition receptor, Mincle, is essential for maintaining the M1 macrophage phenotype in acute renal inflammation.PMID 28017324Read ↗

Clec7a expression in inflammatory macrophages orchestrates progression of acute kidney injurySemantic proximity Read ↗

Macrophages in the kidney in health, injury and repair.Semantic proximity Read ↗

Macrophages in renal disease.Semantic proximity Read ↗

The role of macrophages during acute kidney injury: destruction and repair.Semantic proximity Read ↗

Macrophage polarization in innate immune responses contributing to pathogenesis of chronic kidney diseaseSemantic proximity Read ↗

Pathogenic and protective role of macrophages in kidney disease.Semantic proximity Read ↗

Macrophage Ontogeny, Phenotype, and Function in Ischemia Reperfusion-Induced Injury and Repair.Semantic proximity Read ↗

Dendritic cells and macrophages in the kidney: a spectrum of good and evil.Semantic proximity Read ↗

Dendritic cells in acute kidney injury: cues from the microenvironment.Semantic proximity Read ↗

The Interaction of Pneumocystis with the C-Type Lectin Receptor Mincle Exerts a Significant Role in Host Defense against InfectionSemantic proximity Read ↗

Macrophage phenotype controls long-term AKI outcomes--kidney regeneration versus atrophy.Semantic proximity Read ↗

The myeloid mineralocorticoid receptor controls inflammatory and fibrotic responses after renal injury via macrophage interleukin-4 receptor signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.