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Article

C-type lectin Mincle is an activating receptor for pathogenic fungus, <i>Malassezia</i>

26 Jan 2009

Abstract excerpt

Mincle (also called as Clec4e and Clecsf9) is a C-type lectin receptor expressed in activated phagocytes. Recently, we have demonstrated that Mincle is an FcRgamma-associated activating receptor that senses damaged cells. To search an exogenous ligand(s), we screened pathogenic fungi using cell line expressing Mincle, FcRgamma, and NFAT-GFP reporter. We found that Mincle specifically recognizes the Malassezia...

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Identifiers

PMID: 19171887
DOI: 10.1073/pnas.0805177106

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